{"id":112,"date":"2024-07-28T13:14:02","date_gmt":"2024-07-28T10:14:02","guid":{"rendered":"https:\/\/li.utu.fi\/?page_id=112"},"modified":"2026-01-07T15:00:39","modified_gmt":"2026-01-07T13:00:39","slug":"research","status":"publish","type":"page","link":"https:\/\/li.utu.fi\/?page_id=112","title":{"rendered":"Publications"},"content":{"rendered":"\n
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2026<\/strong><\/p>\n\n\n\n

Zhuang X., Virta J., Liljenb\u00e4ck H., Paasonen L., Airaksinen A. J., Roivainen A., Li X.-G. Longitudinal Monitoring of Nanofibrillar Cellulose Hydrogel Medical Implants in Mice Using Positron Emission Tomography. European Journal of Pharmaceutical Sciences<\/em> 2026<\/strong>, 217<\/em>, 107402.<\/p>\n\n\n\n

DOI:10.1016\/j.ejps.2025.107402<\/a>.<\/p>\n\n\n\n

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2025<\/strong><\/p>\n\n\n\n

Zhuang X., Kunnas J., Ekwe D., Bakay E., Dillemuth P., Liljenb\u00e4ck H., Iqbal I., Rajander J., Low P. S., Knuuti J., Rosenholm J. M., Saraste A., Roivainen A., Li X.-G. [18<\/sup> F]Fluoronicotinic-Acid-Conjugated Folate as a Novel Candidate Positron Emission Tomography Tracer for Inflammation. ACS Omega<\/em> 2025<\/strong>, acsomega.5c10157.<\/p>\n\n\n\n

DOI:10.1021\/acsomega.5c10157<\/a>.<\/p>\n\n\n\n

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\u00d6rd T., Palani S., Giroud Gerbetant J., Bodoy S., L\u00f6nnberg T., Niskanen H., Ravindran A., Holappa L., Chemaly M., Taipale M., \u00d5unap K., Haikonen R., Talukdar H., Sukhavasi K., Liljenb\u00e4ck H., Virta J., Ruotsalainen A.-K., Pierrot-Blanchet C., Miner M. W. G., Moisio O., Rajala N., Li X.-G., Low P. S., Saraste A., Hein\u00e4niemi M., Yl\u00e4-Herttuala S., Bj\u00f6rkegren J. L. M., Hedin U., Matic L., Yvan-Charvet L., Palac\u00edn M., Roivainen A., Kaikkonen M. U. Single-Cell to Pre-Clinical Evaluation of Trem2<\/em> , Folr2<\/em> , and Slc7a7<\/em> as Macrophage-Associated Biomarkers for Atherosclerosis. Cardiovascular Research<\/em> 2025<\/strong>, 121<\/em> (16), 2503\u20132519.<\/p>\n\n\n\n

DOI:10.1093\/cvr\/cvaf210<\/a>.<\/p>\n\n\n\n

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Toyohara J., Elsinga P. H., Todde S., Li X.-G., Aime S., Szymanski W. C., Van Der Meulen N., Cleeren F., Schirrmacher R., Yang H., Savio E., Bentaleb N., Zubillaga M., Chaple Gore I. F., Bourgeois M., Mukherjee A., Pellico J., Kopka K. Highlight Selection of Radiochemistry and Radiopharmacy Developments by Editorial Board. EJNMMI radiopharm. chem.<\/em> 2025<\/strong>, 10<\/em> (1), 65.<\/p>\n\n\n\n

DOI:10.1186\/s41181-025-00387-y<\/a>.<\/p>\n\n\n\n

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Dillemuth P, Ayo A, Airenne TT, L\u00f6vdahl P, Bakay E, Zhuang X, Liljenb\u00e4ck H, Paunonen ST, Kunnas J, Filppu P, Rajander J, Johnson MS, Roivainen A, Salminen TA, Rosenholm JM, Laakkonen P, Li X-G<\/strong>. Utilizing monocarboxylate transporter 1-mediated blood\u2013brain barrier penetration for glioblastoma positron emission tomography imaging with 6-[18<\/sup>F]fluoronicotinic acid. Molecular Pharmaceutics. 2025<\/strong>, Publisher: ACS Publications.<\/p>\n\n\n\n

DOI: 10.1021\/acs.molpharmaceut.5c00457<\/p>\n\n\n\n

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Dillemuth P, Ayo A, Zhuang X, L\u00f6vdahl P, Liljenb\u00e4ck H, K\u00e4rn\u00e4 S, Auchynnikava T, Kunnas J, Ponkamo J, Miner MWG, Rajander J, Rosenholm JM, Roivainen A, Airaksinen AJ, Laakkonen P, Li X-G<\/strong>. Rapid cleavage of 6-[18<\/sup>F]fluoronicotinic acid prosthetic group governs BT12 glioblastoma xenograft uptake: implications for radiolabeling design of biomolecules. EJNMMI Radiopharmacy and Chemistry. 2025<\/strong>, 10:40. Publisher: Springer.<\/p>\n\n\n\n

DOI: https:\/\/doi.org\/10.1186\/s41181-025-00368-1<\/a><\/p>\n\n\n\n

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Atencio Herre E, Li X-G<\/strong>, Liljenback H, Palani S, Andriana P, Jahandideh A, Virta J, Iqbal I, Dillemuth P, Kunnas J, Miner MWG, Rajander J, Mansour AH, Cleveland NA, Srinivasarao M, Low PS, Knuuti J, Saraste A, Roivainen A. Comparing two folate receptor targeted tracers in a rat model of experimental autoimmune myocarditis. ACS Pharmacology & Translational Science<\/em>. 2025<\/strong>, published online. Publisher: ACS Publications.<\/p>\n\n\n\n

DOI:10.1021\/acsptsci.4c00749<\/p>\n\n\n\n

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Andriana P, Palani S, Liljenb\u00e4ck H, Iqbal I, Oikonen V, Virta J, Makrypidi K, Rajander J, Atencio Herre E, Suni A, Jalkanen S, Knuuti J, Martinez-Pomares L, Pirmettis I, Li X-G<\/strong>, Saraste A, Roivainen A. Macrophage mannose receptor CD206-targeted PET imaging in experimental acute myocardial infarction. EJNMMI Research<\/em>. 2025<\/strong>, 15:66. Publisher: Springer.<\/p>\n\n\n\n

DOI: https:\/\/doi.org\/10.1186\/s13550-025-01254-2<\/a><\/p>\n\n\n\n

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2024<\/strong><\/p>\n\n\n\n

Dillemuth P., L\u00f6vdahl P., Karskela T., Ayo A., Ponkamo J., Liljenb\u00e4ck H., Paunonen S., Kunnas J., Rajander J., Tynninen O., Rosenholm J., Roivainen A., Laakkonen P., Airaksinen, A., Li X<\/strong>.-G<\/strong>. Switching the chemoselectivity in the preparation of [18<\/sup>F]FNA-N<\/em>-CooP, a free thiol-containing peptide for PET imaging of fatty acid binding protein 3. Molecular Pharmaceutics<\/em>, 2024<\/strong>, 21:4147-4156. Publisher: ACS Publications. This paper was featured with a cover art.<\/strong><\/p>\n\n\n\n

DOI: 10.1021\/acs.molpharmaceut.4c00546<\/a><\/p>\n\n\n\n

This paper is associated with an interview by the same journal, Voices in Molecular Pharmaceutics: Meet Professor Xiang-Guo Li, an Expert in Radiopharmaceutical Chemistry and Positron Emission Tomography for Improved Imaging of Immunological Disorders and Brain Tumors | Molecular Pharmaceutics (acs.org)<\/a><\/p>\n\n\n\n

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Dillemuth P., Karskela T., Ayo A., Ponkamo J., Kunnas J., Rajander J., Tynninen O., Roivainen A., Laakkonen P., Airaksinen A., Li X<\/strong>.-G<\/strong>. Radiosynthesis, structural identification and in vitro tissue binding study of [18<\/sup>F]FNA-S<\/em>-ACooP, a novel radiopeptide for targeted PET imaging of fatty acid binding protein 3. EJNMMI Radiopharmacy and Chemistry<\/em>, 2024<\/strong>, 9:16. Publisher: Springer.<\/p>\n\n\n\n

DOI: 10.1186\/s41181-024-00245-3<\/a><\/p>\n\n\n\n

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Li A., Jaakkola M.K., Saaresranta T., Kl\u00e9n R., Li X<\/strong>.-G<\/strong>. Analysis of sleep apnea research with a special focus on the use of positron emission tomography as a study tool. Sleep Medicine Reviews<\/em>, 2024<\/strong>, 77:101967. Publisher: Elsevier.<\/p>\n\n\n\n

DOI: https:\/\/doi.org\/10.1016\/j.smrv.2024.101967<\/a>.<\/p>\n\n\n\n

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Eichin D., Rahkila J., Li X<\/strong>.-G<\/strong>., Ekambaram R., Lassfolk R., Leino R., Savolainen J. Mannose receptor independent uptake of transmembrane glycocluster immunostimulant TADM by macrophages. Carbohydrate Research<\/em>, 2024<\/strong>, 541:109166. Publisher: Elsevier.<\/p>\n\n\n\n

DOI: https:\/\/doi.org\/10.1016\/j.carres.2024.109166<\/a>.<\/p>\n\n\n\n

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Andriana P., Fair-M\u00e4kel\u00e4 R., Liljenb\u00e4ck H., K\u00e4rn\u00e4 S., Iqbal I, Makrypidi K., Rajander J., Pirmettis I., Li X<\/strong>.-G<\/strong>., Jalkanen S., Saraste A., Salmi M., Roivainen A. Macrophage mannose receptor CD206 targeting of fluoride-18 labeled mannosylated dextran: a validation study in mice. European Journal of Nuclear Medicine and Molecular Imaging <\/em>2024<\/strong>, 51:2216-2228. Publisher: Springer.<\/p>\n\n\n\n

DOI: 10.1007\/s00259-024-06686-x<\/a><\/p>\n\n\n\n

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Nammas W., Paunonen C., Teuho J., Siekkinen R., Luoto P., K\u00e4kel\u00e4 M., Hietanen A., Viljanen T., Dietz M., J. O. Prior, Li X<\/strong>.-G<\/strong>., Roivainen A., Knuuti J., Saraste A. Imaging of myocardial \u03b1v\u03b23 integrin expression for evaluation of myocardial injury after human acute myocardial infarction. Journal of Nuclear Medicine<\/em>, 2024<\/strong>,65:132-138. Publisher: American Society of Nuclear Medicine and Molecular Imaging, USA.<\/p>\n\n\n\n

DOI: 10.2967\/jnumed.123.266148<\/a><\/p>\n\n\n\n

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Bhowmik A.A., Heikkil\u00e4 T.R.H., Polari L, Virta J, Liljenb\u00e4ck H, Moisio O, Li X<\/strong>.-G<\/strong>., Viitanen R, Jalkanen S, Koffert J, Toivola D.M., Roivainen A. Detection of intestinal inflammation by vascular adhesion protein-1-targeted [68<\/sup>Ga]Ga-DOTA-Siglec-9 positron emission tomography in murine models of inflammatory bowel disease. Molecular Imaging and Biology<\/em>, 2024<\/strong>, 26:322-333. Publisher: Springer.<\/p>\n\n\n\n

DOI: 10.1007\/s11307-023-01885-8<\/a><\/p>\n\n\n\n

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Toyohara J., Vugts D., Kiss O.C., Todde S., Li X<\/strong>.-G<\/strong>., Liu Z., Yang Z., Gillings N., Cazzola E., Szymanski W., van der Meulen N., Reilly R., Taddei C., Schirrmacher R., Li Z., Jorge Lagebo Y., Bentaleb N., de Souza Albernaz M., Lapi S., Ramogida C., Mukherjee A., Ajenjo J., Deuther-Conrad W., Bourdeau C. Highlight selection of radiochemistry and radiopharmacy developments by editorial board. EJNMMI Radiopharmacy and Chemistry<\/em>, 2024<\/strong>, 9:42. Publisher: Springer.<\/p>\n\n\n\n

DOI: https:\/\/doi.org\/10.1186\/s41181-024-00268-w<\/a><\/p>\n\n\n\n

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2023<\/strong><\/p>\n\n\n\n

Andriana P., Makrypidi K., Liljenb\u00e4ck H., Rajander J., Saraste A., Pirmettis I., Roivainen A., Li X<\/strong>.-G<\/strong>. Aluminium fluoride-18 labeled mannosylated dextran: radiosynthesis and initial preclinical PET studies. Molecular Imaging and Biology, <\/em>2023<\/strong>, 25:1094-1103. Publisher: Springer.<\/p>\n\n\n\n

DOI: 10.1007\/s11307-023-01816-7<\/a><\/p>\n\n\n\n

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Miner M.W.G., Liljenb\u00e4ck H., Virta J., K\u00e4rn\u00e4 S., Viitanen R., Elo P., Gardberg M., Teuho J., Saipa P., Rajander J., Mansour A.H., Cleveland N.A., Low P.S., Li X<\/strong>.-G<\/strong>., Roivainen A. High folate receptor expression in human and rat gliomas: Al[18<\/sup>F]F-NOTA-folate shows high tumour-to-brain uptake ratio in glioma rat model. Frontiers in Immunology<\/em>, 2023<\/strong>, 14:1145473. Publisher: Frontiers Media S.A. <\/p>\n\n\n\n

DOI: 10.3389\/fimmu.2023.1145473<\/a><\/p>\n\n\n\n

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Auchynnikava T., Antti \u00c4, Liljenb\u00e4ck H., J\u00e4rvinen J., Andriana P., Kovacs L., Rautio J., Rajander J., Virta P., Roivainen A., Li X<\/strong>.-G<\/strong>., Airaksinen A. Tetrazine glycoconjugate for pretargeted PET imaging of trans-cyclooctene functionalized molecular spherical nucleic acids. ACS Omega<\/em>. 2023<\/strong>. 8:45326\u201345336. Publisher: American Chemical Society. <\/p>\n\n\n\n

DOI: 10.1021\/acsomega.3c04041<\/a><\/p>\n\n\n\n

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Jahandideh A, Virta J, Li X<\/strong>.-G<\/strong>., Liljenb\u00e4ck H, Moisio O, Ponkamo J, Rajala N, Alix M, Lehtonen J, M\u00e4yr\u00e4np\u00e4\u00e4 MI, Salminen TA, Knuuti J, Jalkanen S, Saraste A, Roivainen A. Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis. Journal of Nuclear Cardiology<\/em>, 2023<\/strong>, 30:2760\u20132772. Publisher: Springer. <\/p>\n\n\n\n

DOI: 10.1007\/s12350-023-03371-8<\/a><\/p>\n\n\n\n

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Torrieri G., Iqbal I., Fontana F., Talman V., Liljenb\u00e4ck H., Andriana P., Nammas W., Li X.-G., Teesalu T., Roivainen A., Hirvonen J., Ruskoaho H., Vimalkumar Balasubramanian V., Saraste A., Santos H.A.  In vivo evaluation of macrophage hitchhiking nanoparticles for the treatment of myocardial infarction. Advanced Functional Materials<\/em>, 2023, 33:2303658. Publisher: Wiley. <\/p>\n\n\n\n

DOI:  https:\/\/doi.org\/10.1002\/adfm.202303658<\/a><\/p>\n\n\n\n

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Moisio O., Virta J., Yatkin E., Palani S., Viitanen R., Miner M.W.G., Oikonen V., Tolvanen T., Vugts D.J., Taimen P., Li X<\/strong>.-G<\/strong>., Hollm\u00e9n M., Jalkanen S., Roivainen A. Preclinical evaluation of a humanized antibody against common lymphatic endothelial and vascular endothelial receptor-1, 89<\/sup>Zr-desferrioxamine-bexmarilimab, in a rabbit model of renal fibrosis. Journal of Nuclear Medicine<\/em>, 2023<\/strong>, 64:555-560. Publisher: American Society of Nuclear Medicine and Molecular Imaging, USA.<\/p>\n\n\n\n

DOI: 10.2967\/jnumed.122.264725<\/a><\/p>\n\n\n\n

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2022<\/strong><\/p>\n\n\n\n

Suilamo S., Li X<\/strong>.-G<\/strong>., Lankinen P., Oikonen V., Tolvanen T., Luoto P., Viitanen R., Saraste A., Sepp\u00e4nen M., Piril\u00e4 L., Hohenthal U., Roivainen A. 68<\/sup>Ga-Citrate positron emission tomography of healthy men: whole-body biodistribution kinetics and radiation dose estimates. Journal of Nuclear Medicine<\/em>, 2022<\/strong>, 63:1598-1603. Publisher: American Society of Nuclear Medicine and Molecular Imaging, USA.<\/p>\n\n\n\n

DOI: 10.2967\/jnumed.122.263884<\/a><\/p>\n\n\n\n

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Viitanen R., Virtanen H., Liljenb\u00e4ck H., Moisio O., Li X<\/strong>.-G<\/strong>., Nicolini V., Richard M., Klein C., Nayak T., Jalkanen S., Roivainen A. [68<\/sup>Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic changes of FAP-targeted IL2 variant immunotherapy in B16-FAP melanoma mice. Fronters in Immunology<\/em>, 2022<\/strong>, 13:901693. Publisher: Frontiers Media SA, Switzerland.<\/p>\n\n\n\n

DOI: 10.3389\/fimmu.2022.901693<\/a><\/p>\n\n\n\n

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Palani S., Miner MWG, Virta J., Liljenb\u00e4ck H., Eskola O., \u00d6rd T., Ravindran A., Kaikkonen-M\u00e4\u00e4tt\u00e4 M., Knuuti J., Li X.-G., Saraste A., Roivainen A. Exploiting glutamine consumption in atherosclerotic lesions by positron emission tomography tracer (2S<\/em>,4R<\/em>)-4-18<\/sup>F-fluoroglutamine. Frontiers in Immunology<\/em>, 2022, 13:821423. Publisher: Frontiers Media Ltd. Switzerland. <\/p>\n\n\n\n

DOI: 10.3389\/fimmu.2022.821423<\/a><\/p>\n\n\n\n

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Li X.<\/strong>–G<\/strong>., Velikyan I, Viitanen R, Roivainen A. New PET radiopharmaceuticals for imaging inflammatory diseases. In: Signore A. (eds) Nuclear Medicine and Molecular Imaging<\/em>. ISBN: 978-0-12-822980-4. 2022<\/strong>, 3:734\u2013743. Elsevier.<\/p>\n\n\n\n

DOI: https:\/\/doi.org\/10.1016\/B978-0-12-822960-6.00075-2<\/a><\/p>\n\n\n\n

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2021<\/strong><\/p>\n\n\n\n

Miner M.W.G., Liljenb\u00e4ck H., Virta J., Helin S., Eskola O., Elo P., Teuho J., Sepp\u00e4l\u00e4 K., Oikonen V., Yang G., Kindler-R\u00f6hrborn A., Minn H., Li X<\/strong>.-G<\/strong>., Roivainen A. Comparison of: (2S<\/em>, 4R<\/em>)-4-[18<\/sup>F]Fluoroglutamine, [11<\/sup>C]methionine, and 2-deoxy-2-[18<\/sup>F]fluoro-D<\/em>-glucose and two small-animal PET\/CT systems imaging rat gliomas. Frontiers in Oncology<\/em>, 2021<\/strong>, 11:76732. Publisher: Frontiers Media Ltd. Switzerland.<\/p>\n\n\n\n

DOI: 10.3389\/fonc.2021.730358<\/a><\/p>\n\n\n\n

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Jahandideh A., St\u00e5hle M., Virta J., Li X<\/strong>.-G<\/strong>., Liljenb\u00e4ck H., Moisio O., Knuuti J., Roivainen A., Saraste A. Evaluation of [68<\/sup>Ga]Ga-NODAGA-RGD for PET imaging of rat autoimmune myocarditis. Frontiers in Medicine<\/em>. 2021<\/strong>, 8:783596. Publisher: Frontiers Media Ltd. Switzerland.<\/p>\n\n\n\n

DOI: 10.3389\/fmed.2021.783596<\/a><\/p>\n\n\n\n

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Elo P, Li X<\/strong>.-G<\/strong>., Liljenb\u00e4ck H, Gardberg M, Moisio O, Miner M, Virta J, Saraste A, Srinivasarao M, Pugh M, Low PS, Knuuti J, Jalkanen S, Airas L, Lu YJ, Roivainen A. Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis. Journal of Neuroinflammation<\/em>, 2021<\/strong>, 18:30. Publisher: Springer.<\/p>\n\n\n\n

DOI: 10.1186\/s12974-021-02073-7<\/a><\/p>\n\n\n\n

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Gr\u00f6nman M., Moisio O., Li X.-G., Toimela T., Huttala O., Heinonen T., Knuuti J., Roivainen A., Saraste A. Association between [68<\/sup>Ga]NODAGA-RGD uptake and dynamics of angiogenesis in a human cell-based 3D\u2013model. Molecular Biology Reports<\/em>, 2021, 48:5347\u20135353. Publisher: Springer.<\/strong> <\/p>\n\n\n\n

DOI: 10.1007\/s11033-021-06513-8<\/a><\/strong><\/p>\n\n\n\n

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St\u00e5hleM., HellbergS., Virta J., Liljenb\u00e4ckH., Mets\u00e4l\u00e4O., LiX.-G., JauhiainenM., SaukkoP., Yl\u00e4-herttualaS., NuutilaP., KnuutiJ., SarasteA., RoivainenA. Evaluation of glucagon-like peptide-1 receptor expression in non-diabetic and diabetic atherosclerotic mice using PET tracer 68<\/sup>Ga-NODAGA-exendin-4. AJP-Endocrinology and Metabolism, <\/em>2021, 320:E989-E998. Publisher: American Physiological Society, USA. <\/p>\n\n\n\n

DOI: 10.1152\/ajpendo.00465.2020<\/a><\/p>\n\n\n\n

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Aime S., Al-Qahtani M., Behe M., Bormans G., Carlucci G., DaSilva J. N., Decristoforo C., Duatti A., Elsinga P. H., Kopka K., Li X<\/strong>.-G<\/strong>., Liu Z., Mach R. H., Middel O., Passchier J., Patt M., Penuelas I., Rey A., Scott P. J. H., Todde S., Toyohara J., Vugts D., Zhi Y. Highlight selection of radiochemistry and radiopharmacy developments by Editorial Board. EJNMMI Radiopharmacy and Chemistry<\/em>. 2021<\/strong>, 6:13. Publisher: Springer. <\/p>\n\n\n\n

DOI: 10.1186\/s41181-021-00128-x<\/a><\/p>\n\n\n\n

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Al-Qahtani M., Behe M., Bormans G., Carlucci G., Dasilva J., Decristoforo C., Elsinga PH, Kopka K., Li X<\/strong>.-G<\/strong>., Mach R., Middel O., Passchier J., Patt M., Penuelas I, Rey I, Scott P.J.H., Todde S., Toyohara J., Vugts D. Highlight selection of radiochemistry and radiopharmacy developments by Editorial Board. EJNMMI Radiopharmacy and Chemistry<\/em>. 2021<\/strong>, 6:5. Publisher: Springer. <\/p>\n\n\n\n

DOI: https:\/\/doi.org\/10.1186\/s41181-020-00118-5<\/a><\/p>\n\n\n\n

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Viitanen R., Moisio O., Lankinen P., Li X<\/strong>.-G<\/strong>., Koivum\u00e4ki M., Suilamo S., Tolvanen T., Taimen K., Mali M., Kohonen I., Koskivirta I., Oikonen V., Virtanen H., Santalahti K., Autio A., Saraste A., Piril\u00e4 L., Nuutila P., Knuuti J., Jalkanen S., Roivainen A. First-in-humans study of 68<\/sup>Ga-DOTA-Siglec-9, a PET ligand targeting vascular adhesion protein 1. Journal of Nuclear Medicine<\/em>, 2021<\/strong>, 62:577-583. Publisher: American Society of Nuclear Medicine and Molecular Imaging, USA. This paper was featured with a cover art<\/strong>.<\/p>\n\n\n\n

DOI: 10.2967\/jnumed.120.250696<\/a><\/p>\n\n\n\n

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2020<\/strong><\/p>\n\n\n\n

Moisio O., Palani S., Virta J., Elo P., Liljenb\u00e4ck H., Miner M., K\u00e4kel\u00e4 M., Atencio Herre E., Tolvanen T., Marjam\u00e4ki P., \u00d6rd T., Hein\u00e4niemi M., Kaikkonen-M\u00e4\u00e4tt\u00e4 M., Zhang F., Srinivasarao M., Knuuti J., Low P.S., Saraste A., Li X<\/strong>.-G<\/strong>., Roivainen A. Radiosynthesis and preclinical evaluation of [68<\/sup>Ga]Ga-NOTA-Folate for PET imaging of folate receptor \u03b2-positive macrophages. Scientific Reports<\/em>, 2020<\/strong>, 10:13593. Publisher: Springer Nature.<\/p>\n\n\n\n

DOI: 10.1038\/s41598-020-70394-3<\/a><\/p>\n\n\n\n

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Miner M.W.G., Liljenb\u00e4ck H., Virta J., Merisaari J, Oikonen V, Westermark J, Li X<\/strong>.-G<\/strong>., Roivainen A. (2S<\/em>, 4R<\/em>)-4-[18<\/sup>F]Fluoroglutamine for in vivo PET imaging of glioma xenografts in mice:  an evaluation of multiple pharmacokinetic models. Molecular Imaging and Biology<\/em>, 2020<\/strong>, 22:969-978. Publisher: Springer.<\/p>\n\n\n\n

DOI: 10.1007\/s11307-020-01472-1<\/a><\/p>\n\n\n\n

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Jahandideh A., Uotila S., St\u00e5hle M., Virta J., Li X<\/strong>.-G<\/strong>., Kyt\u00f6 V., Marjam\u00e4ki P., Liljenb\u00e4ck H., Taimen P., Oikonen V., Lehtonen J., M\u00e4yr\u00e4np\u00e4\u00e4 M.I., Chen Q, Low P.S., Knuuti J, Roivainen A, Saraste A. Folate receptor \u03b2 targeted PET imaging of macrophages in autoimmune myocarditis. Journal of Nuclear Medicine, <\/em>2020<\/strong>, 61:1643-1649. Publisher: American Society of Nuclear Medicine and Molecular Imaging, USA. DOI: 10.2967\/jnumed.119.241356<\/a><\/p>\n\n\n\n

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Sir\u00e9n S., Dahlstr\u00f6m KM, Putreddy R, Rissanen K, Salminen TA, Scheinin M, Li X.-G., Liljeblad A. Candida antarctica lipase A-based enantiorecognition of a highly
strained 4-dibenzocyclooctynol (DIBO) used for PET imaging. Molecules<\/em>, 2020, 25:897. Publisher: Molecular Diversity Preservation International (MDPI)<\/a>. <\/p>\n\n\n\n

DOI: 10.3390\/molecules25040879<\/a><\/p>\n\n\n\n

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St\u00e5hle M., Kyt\u00f6 V. Kiugel M., Liljenb\u00e4ck H., Mets\u00e4l\u00e4 O., K\u00e4kel\u00e4 M., Li X<\/strong>.-G<\/strong>., Oikonen V., Saukko P., Nuutila P., Knuuti J., Roivainen A., Saraste A. Glucagon-like peptide-1 receptor expression after myocardial infarction: imaging study using [68<\/sup>Ga]NODAGA-exendin-4 positron emission tomography. Journal of Nuclear Cardiology<\/em>, 2020<\/strong>. 27:2386-2397. Publisher: Springer. <\/p>\n\n\n\n

DOI: 10.1007\/s12350-018-01547-1<\/a><\/p>\n\n\n\n

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2019<\/strong><\/p>\n\n\n\n

Elo P., Li X.-G., Liljenb\u00e4ck H., Helin S., Teuho J., Koskensalo K., Saunavaara V., Marjam\u00e4ki P., Oikonen V., Virta J., Chen Q., Low PS, Knuuti J., Jalkanen S., Airas L., Roivainen A. Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rat. Journal of Neuroinflammation<\/em>, 2019, 16:252. Publisher: Springer.<\/p>\n\n\n\n

DOI: 10.1186\/s12974-019-1612-3<\/a><\/p>\n\n\n\n

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Hagert C., Siitonen R., Li X.-G., Liljenb\u00e4ck H., Roivainen A., Holmdahl R. Rapid spread of mannan to the immune system, skin and joints within six hours after local exposure. Clinical and Experimental Immunology<\/em>, 2019, 196:383-391. Publisher: Wiley.<\/p>\n\n\n\n

DOI: 10.1111\/cei.13268<\/a><\/p>\n\n\n\n

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Benkherouf A., Taina K.-R., Meera P., Aalto A.J., Li X.-G., Soini S.L., Wallner M., Uusi-Oukari M. Extrasynaptic \u03b4-GABAA receptors are high affinity muscimol receptors. Journal of Neurochemistry<\/em>, 2019, 149:41-53. Publisher: Wiley.<\/p>\n\n\n\n

DOI: 10.1111\/jnc.14646<\/a><\/p>\n\n\n\n

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Chrusciel P., Yatkin E., LiX.-G., Jaakkola U.-M., KnuutiJ., JalkanenS., RoivainenA. <\/sup>Safety study of single-dose intravenously administered DOTA-Siglec-9 peptide in Sprague Dawley rats. International Journal of Toxicology<\/em>, 2019, 38:4-11. Publisher: SAGE Publishing.<\/p>\n\n\n\n

DOI: 10.1177\/1091581818821606<\/a><\/p>\n\n\n\n

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2018<\/strong><\/p>\n\n\n\n

Kiugel M., Hellberg S., K\u00e4kel\u00e4 M., Liljenb\u00e4ck H., Saanijoki T., Li X.-G., Tuomela J., Knuuti J., Saraste A., Roivainen A. Evaluation of [68<\/sup>Ga]Ga-DOTA-TCTP-1 for the Detection of Metalloproteinase 2\/9 Expression in Mouse Atherosclerotic Plaques. Molecules<\/em>, 2018, 23:3168. Publisher: Molecular Diversity Preservation International (MDPI)<\/a>.<\/p>\n\n\n\n

DOI: 10.3390\/molecules23123168<\/p>\n\n\n\n

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Kiugel M., Kyt\u00f6 V., Saanijoki T., Liljenb\u00e4ck H., Mets\u00e4l\u00e4 O., St\u00e5hle M., Tuomela J., Li X.-G.<\/strong>, Saukko P., Knuuti J., Roivainen A., Saraste A. Evaluation of 68<\/sup>Ga-labeled peptide tracer for detection of gelatinase expression after myocardial infarction in rat. Journal of Nuclear Cardiology<\/em> 2018<\/strong>, 25:1114-1123. Publisher: Springer.<\/p>\n\n\n\n

DOI: 10.1007\/s12350-016-0744-4<\/p>\n\n\n\n

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Silvola J.M.U., Li X<\/strong>.-G<\/strong>., Virta J., Marjam\u00e4ki P., Liljenb\u00e4ck H., Hyt\u00f6nen J.P., Tarkia M., Saunavaara V., Hurme S., Hakovirta H., Yl\u00e4-Herttuala S., Saukko P., Chen Q., Low P.S., Knuuti J., Saraste A., Roivainen A. Aluminum fluoride-18 labeled folate enables in vivo<\/em> detection of atherosclerotic plaque inflammation by positron emission tomography. Scientific Reports<\/em>, 2018<\/strong>, 8:9720. Publisher: Springer Nature.<\/p>\n\n\n\n

DOI: 10.1038\/s41598-018-27618-4<\/p>\n\n\n\n

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K\u00e4kel\u00e4 M., Luoto P., Viljanen T., Virtanen H., Liljenb\u00e4ck H., Jalkanen S., Knuuti J., Roivainen A., Li X<\/strong>.-G<\/strong>. Adventures in radiosynthesis of clinical grade [68Ga]Ga-DOTA-Siglec-9. RSC Advances<\/em>, 2018<\/strong>, 8:8051-8056. Publisher: The Royal Society of Chemistry, UK.<\/p>\n\n\n\n

DOI: 10.1039\/c7ra12423f<\/p>\n\n\n\n

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Moisio O., Siitonen R., Liljenb\u00e4ck H., Suomela E., Jalkanen S., Li X<\/strong>.-G<\/strong>., Roivainen A. Exploring alternative radiolabeling strategies for sialic acid-binding immunoglobulin-like lectin 9 peptide: [68<\/sup>Ga]Ga- and [18<\/sup>F]AlF-NOTA-Siglec-9. Molecules<\/em>, 2018<\/strong>, 23:305. Publisher: Molecular Diversity Preservation International (MDPI)<\/a>.<\/p>\n\n\n\n

DOI: 10.3390\/molecules23020305<\/p>\n\n\n\n

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2017<\/strong><\/p>\n\n\n\n

Virtanen H., Silvola J., Autio A., Li X<\/strong>.-G<\/strong>., Liljenb\u00e4ck H., Hellberg S., Siitonen R., St\u00e5hle M., K\u00e4kel\u00e4 M., Airaksinen A. J., Helariutta K., Tolvanen T., Veres T. Z., Saraste A., Knuuti J., Jalkanen S., Roivainen A. Comparison of 68<\/sup>Ga-DOTA-Siglec-9 and 18<\/sup>F-fluorodeoxyribose-siglec-9: inflammation imaging and radiation dosimetry. Contrast Media & Molecular Imaging<\/em>. 2017<\/strong>, Article ID 7645070. Publisher: Wiley & Hindawi.<\/p>\n\n\n\n

DOI: 10.1155\/2017\/7645070<\/p>\n\n\n\n

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Hellberg S., Silvola J.M.U., Kiugel M., Liljenb\u00e4ck H., Savisto N., Li X<\/strong>.-G<\/strong>., Thiele A., Lehmann L, Heinrich T., Vollmer S., Laine V.J.O., Yl\u00e4-Herttuala S., Knuuti J., Roivainen A., Saraste A. 18-kDa translocator protein ligand 18<\/sup>F-FEMPA: biodistribution and uptake into atherosclerotic plaques in mice. Journal of Nuclear Cardiology<\/em> 2017<\/strong>, 24:862-871. Publisher: Springer.<\/p>\n\n\n\n

DOI: 10.1007\/s12350-016-0527-y<\/p>\n\n\n\n

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2016<\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n

Li X.-G<\/strong>., Hagert C., Siitonen R., Virtanen H., Sareila O., Liljenb\u00e4ck H., Tuisku J., Knuuti J., Bergman J., Holmdahl R., Roivainen A. 18<\/sup>F-Labeling of mannan for inflammation research with positron emission tomography. ACS Medicinal Chemistry Letters, <\/em>2016<\/strong>,7:826-830. Publisher: American Chemical Society, USA. This paper was featured with a cover art<\/strong>.<\/p>\n\n\n\n

DOI: 10.1021\/acsmedchemlett.6b00160<\/p>\n\n\n\n

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Kein\u00e4nen O.,Li X<\/strong>.-G<\/strong>., Chenna N.K., Lumen D., Ott J., Molthoff C.F.M., Sarparanta M.,Helariutta K., Vuorinen T., Windhorst A.D., Airaksinen A.J. A new highly reactive and low lipophilicity fluorine-18 labeled tetrazine derivative for pretargeted PET imaging. ACS Medicinal Chemistry Letters, <\/em>2016<\/strong>, 7:62-66. Publisher: American Chemical Society, USA.<\/p>\n\n\n\n

DOI: 10.1021\/acsmedchemlett.5b00330<\/p>\n\n\n\n

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Rinne P., Hellberg S., Kiugel M., Virta J., Li X<\/strong>.-G<\/strong>., K\u00e4kel\u00e4 M., Helariutta K., Luoto P., Liljenb\u00e4ck H., Hakovirta H., Gardberg M., Airaksinen A. J., Knuuti J., Saraste A., Roivainen A. Comparison of somatostatin receptor 2-targeting PET tracers in the detection of mouse atherosclerotic plaques. Molecular Imaging and Biology<\/em>, 2016<\/strong>, 18:99-108. Publisher: Springer.<\/p>\n\n\n\n

DOI: 10.1007\/s11307-015-0873-1<\/p>\n\n\n\n

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<\/p>\n","protected":false},"excerpt":{"rendered":"

2026 Zhuang X., Virta J., Liljenb\u00e4ck H., Paasonen L., Airaksinen A. J., Roivainen A., Li X.-G. Longitudinal Monitoring of Nanofibrillar Cellulose Hydrogel Medical Implants in Mice Using Positron Emission Tomography. European Journal of Pharmaceutical Sciences 2026, 217, 107402. DOI:10.1016\/j.ejps.2025.107402. 2025 Zhuang X., Kunnas J., Ekwe D., Bakay E., Dillemuth P., Liljenb\u00e4ck H., Iqbal I., Rajander […]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-112","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/li.utu.fi\/index.php?rest_route=\/wp\/v2\/pages\/112","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/li.utu.fi\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/li.utu.fi\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/li.utu.fi\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/li.utu.fi\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=112"}],"version-history":[{"count":33,"href":"https:\/\/li.utu.fi\/index.php?rest_route=\/wp\/v2\/pages\/112\/revisions"}],"predecessor-version":[{"id":496,"href":"https:\/\/li.utu.fi\/index.php?rest_route=\/wp\/v2\/pages\/112\/revisions\/496"}],"wp:attachment":[{"href":"https:\/\/li.utu.fi\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}